twobirds.comSadly, there haven't been many if any recent studies on Lysine for chilly sore treatments. Take 1000mg of Lysine each day, day by day, for a year. The exception to the rule is the DOT1 household, members of which methylate K79 in the globular region of histone H3 and which are structurally not associated to SET-domain proteins four - 6 Latest work suggests that SET-domain-containing proteins methylate a couple of proteins in addition to histones (see later)